Mechanism of Action

VARGATEF®: A triple mode of action

Vargatef MOA: A triple mode of action
  • VARGATEF® targets 3 signalling pathways crucial to angiogenesis regulation and escape mechanisms1-4

  • Targeting these multiple receptors including potential escape pathways may prevent the tumour from finding an alternative route to grow and spread4-5

VEGFR  = vascular endothelial growth factor receptor
PDGFR = platelet-derived growth factor receptor
FGFR = fibroblast growth factor receptor



References

1
Reck M. Expert Rev Anticancer Ther. 2015; 15:579-594.
2
VARGATEF® SmPC.
3
Hilberg F et al. Cancer Res 2008; 68:4774-4782.
4
Rashdan S, Hanna N. Expert Opin Pharmacother 2014; 15:729-39.
5
Santos ES et al. Invest New Drugs 2012; 30:1261-9.